Developmental changes in rat renal 11β-hydroxysteroid dehydrogenase
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چکیده
منابع مشابه
Zearalenone Inhibits Rat and Human 11β-Hydroxysteroid Dehydrogenase Type 2
Zearalenone is a mycotoxin produced by Fusarium spp. 11β-Hydroxysteroid dehydrogenases, isoforms 1 (HSD11B1) and 2 (HSD11B2), have been demonstrated to be the regulators of the local level of active glucocorticoid, which has a broad range of physiological actions. In the present study, the potency of zearalenone was tested for the inhibition of HSD11B1 and HSD11B2 in rat and human tissues. Zear...
متن کاملChanges in 11β-Hydroxysteroid Dehydrogenase and Glucocorticoid Receptor Expression in Kawasaki Disease
BACKGROUND AND OBJECTIVES This study aims to investigate the significance of changes in the expression 11β-hydroxysteroid dehydrogenase (11β-HSD) and glucocorticoid receptor (GR) for the development of Kawasaki disease (KD). SUBJECTS AND METHODS Real-time polymerase chain reaction was performed to determine the mRNA expression levels of GR and 11β-HSD in peripheral blood monocytes, both in th...
متن کاملAge-related changes in 11β-hydroxysteroid dehydrogenase type 2 activity in normotensive subjects.
BACKGROUND Impairment in 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) activity results in inefficient inactivation of cortisol to cortisone, and it can trigger hypertension through activation of the mineralocorticoid receptor. Information about age-related changes in 11β-HSD2 activity and its physiological consequences is scarce. Our aim was to investigate whether 11β-HSD2 activity is age...
متن کامل11β-Hydroxysteroid Dehydrogenase-2 and Salt-Sensitive Hypertension.
1335 Glucocorticoid intracellular metabolism, catalyzed by the 2 isozymes of 11β-hydroxysteroid dehydrogenase (11βHSD), determines the corticosteroid action on target tissues. 11β-HSD1 functions as a reductase in most cells and catalyzes the regeneration of active glucocorticoids, thereby amplifying their action. This isozyme is widely expressed in liver, adipose tissue, muscle, pancreatic isle...
متن کاملBenzofuran derivatives inhibit 11β-hydroxysteroid dehydrogenase type 1 activity in rat adipose tissue.
Excess glucocorticoids promote visceral obesity and insulin resistance. The main regulator of intracellular glucocorticoid levels are 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which converts inactive glucocorticoid into bioactive glucocorticoid such as cortisol in humans and corticosterone in rodents; therefore, the inhibition of 11β-HSD1 has considerable therapeutic potential for met...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1994
ISSN: 0085-2538
DOI: 10.1038/ki.1994.91